HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 24770940, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 68510123 | HCID 68510123 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Product | HCID 24770940 | HCID 24770940 | — |
Reaction Steps
The compound of Example 2 is dissolved in DMF and subsequently N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC.HCl; 1.5 eq), hydroxybenzotriazole (HOBt; 1.3 eq), NH4OH 25% in water (1.2 eq) and diisopropylethylamine (1.5 eq) are added. After 16 hours at room temperature the reaction mixture is concentrated and purified on silica gel (CH2Cl2/methanol 95/5→CH2Cl2/methanol/acetic acid50% 90/10/0.125 as mobile phase) resulting in pure title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799812B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-e428ff52c35b4ccea6737943d0600acc |
| Source note | uspto-grants-2010_09 |