HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 68507277, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 43219016 | HCID 43219016 | — |
| Reactant | HCID 178513263 | HCID 178513263 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68507277 | HCID 68507277 | — |
Reaction Steps
4-(2-Methoxycarbonyl-ethylsulfamoyl)-benzoic acid (1 eq) is dissolved in DMF and EDC.HCl (1.3 eq) and HOBt (1.1 eq) are added. After 30 minutes at room temperature N-hydroxy-2-trifluoromethyl-biphenyl-4-carboxamidine (1 eq) is added and the reaction mixture is kept at 90° C. for 16 hours. After removal of the solvent the residue is dissolved in ethyl acetate and extracted with saturated NaHCO3 solution. Title compound is obtained after drying of the organic phase over Na2SO4 on silica gel using c-hexane/ethyl acetate/CH2Cl2 8/2/1 as mobile phase.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799812B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-4ad94e4ccc894b2da01a27e805ad84b7 |
| Source note | uspto-grants-2010_09 |