Sodium hydride → HCID 68682445, compound

Participants

Reaction Steps

With cooling with ice, sodium hydride (30% liquid paraffin added) (6 mg) was added to an N,N-dimethylformamide (2 ml) solution of the indole compound (50 mg) obtained in Example 3, then 2-(trimethylsilyl)ethoxy methyl chloride (24 mg) was added, and stirred at room temperature for 1 hour. With cooling with ice, aqueous saturated ammonium chloride solution was added, then extracted with ethyl acetate, and the organic layer was washed with water and saturated saline water. After dried, the solvent was evaporated away under reduced pressure, and the residue was purified by partitioning reversed-phase liquid chromatography to obtain the entitled compound.

Provenance & Evidence