Hydrochloric Acid → HCID 68507960, compound

Participants

Reaction Steps

The compound obtained in Example 25, (±)-3-[3-(4-cyano-3-trifluoromethyl-phenoxy)-4,4-dimethyl-2-oxo-pyrrolidin-1-ylmethyl]-benzoic acid methyl ester, (0.128 g, 0.29 mmol) was dissolved in 4 mL THF and 1.0 mL 1 M NaOH was added. The reaction was stirred at ambient temperature overnight. The reaction mixture was acidified with 1 N HCl to pH ˜3 and extracted into ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate and concentrated in vacuo. The material was triturated with diethyl ether and filtered to obtain the carboxylic acid as a white solid (0.105 g, 85%).

Provenance & Evidence