Hydrochloric Acid → HCID 68509093, compound

Participants

Reaction Steps

The compound obtained in Example 29, 5-[3-(4-cyano-3-trifluoromethyl-phenoxy)-4,4-dimethyl-2-oxo-pyrrolidin-1-ylmethyl]-furan-2-carboxylic acid ethyl ester, (0.461 g, 1.024 mmol) was dissolved in 5 mL THF and 1.5 mL 1 M NaOH was added. The reaction was stirred at ambient temperature overnight. The reaction mixture was acidified with 1 N HCl to pH ˜3 and extracted into ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain the carboxylic acid, 5-[3-(4-cyano-3-trifluoromethyl-phenoxy)-4,4-dimethyl-2-oxo-pyrrolidin-1-ylmethyl]-furan-2-carboxylic acid, as a white solid (0.417 g).

Provenance & Evidence