Potassium Carbonate → HCID 58775905, compound

Participants

Reaction Steps

K2CO3 (0.2 mmol, 0.03 g) and a Pd(dppf)2 catalyst:DCM complex (1:1) (0.03 mmol, 0.02 g) was added to a mixture of 3-bromo-N-{4-[(cyclohexyl-methyl-amino)-methyl]-phenyl}-benzamide Compound 10f (0.1 mmol, 0.04 g) and p-tolylboronic acid Compound 11a (0.12 mmol, 0.02 g) in a mixed solution of toluene/ethanol/water (7 mL/1 mL/1 mL). The resulting suspension was heated to reflux for 5 hrs, concentrated and purified with preparative TLC (10% MeOH/2% Et3N/88% EtOAc) to yield 4′-methyl-biphenyl-3-carboxylic acid {4-[(cyclohexyl-methyl-amino)-methyl]-phenyl}amide Compound 11b (0.02 g, 48%). MS m/e 413 (M+1).

Provenance & Evidence