HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Carbodiimide | HCID 160435 | — |
| Reactant | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| Reactant | 5-(2,2,2-Trifluoroacetyl)thiophene-2-carboxylic acid | HCID 24274701 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide | HCID 86628838 | — |
Reaction Steps
To a solution of Example 1, A1 in DCM was added Pol-supported carbodiimide (2 eq) and the suspension was stirred at RT for 30 min. A solution of 2-aminoacetophenone HCl (1.1 eq) and Et3N (1.1 eq) in DCM was added and the resulting suspension was stirred at RT overnight. The resin was filtered, washed with DCM, and the filtrate was evaporated at reduced pressure. Purification by flash chromatography on silica gel eluting with DCM gave the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799825B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-8ee931b835914bd4a9f23d64613a623f |
| Source note | uspto-grants-2010_09 |