Ammonium Chloride → HCID 67148527, compound

Participants

Reaction Steps

TBAF (1M in THF, 1.12 mL, 1.12 mmol) was added to a sol. of N-{2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl}-acetamide (190 mg, 0.555 mmol) in THF (7.10 mL) at 0° C. The mixture was stirred for 1 h while warming up to rt. Aq. sat. NH4Cl was added, and the mixture was extracted with EtOAc (3×). The org. layer was dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the crude by FC (CH2Cl2/MeOH 19:1) yielded the title compound (100 mg, 79%). LC-MS: tR=0.67 min; ES+: 284.11.

Provenance & Evidence