HCID 86622964, compound → HCID 86622966, compound

Participants

Reaction Steps

MnO2 (1.22 g, 12.6 mmol) was added to a sol. of (4-chloro-3-hydroxymethyl-benzyl)-(2-fluoro-ethyl)-carbamic acid tert-butyl ester (801 mg, 2.52 mmol) in CH3CN (50 mL). The mixture was stirred at rt for 4.5 h, and MnO2 (1.22 g, 12.6 mmol) was added again. The mixture was stirred for 1 h, and was filtered over Celite. The precipitate was washed with CH3CN and CH2Cl2. The filtrate was evaporated under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (800 mg, quantitative yield) that was used further without purification. LC-MS: tR=1.01 min.

Provenance & Evidence