HCID 68505800, compound → HCID 86622968, compound

Participants

Reaction Steps

MnO2 (475 mg, 4.92 mmol) was added to a sol. of (4-chloro-3-hydroxymethyl-benzyl)-ethyl-carbamic acid tert-butyl ester (295 mg, 0.984 mmol) in CH3CN (20 mL). The mixture was stirred at rt for 5 h and MnO2 (475 mg, 0.984 mmol) was added again. The mixture was stirred for 1 h, and the mixture was filtered over Celite, and washed with CH3CN and CH2Cl2. Evaporation of the solvents under reduced pressure yielded the crude title compound (240 mg, 82%) that was used further without purification. LC-MS: tR=1.02 min.

Provenance & Evidence