HCID 131728342, compound → HCID 68506130, compound

Participants

Reaction Steps

In a 250 mL round-bottom flask equipped with a magnetic stirrer is suspended compound B1 (1.17 g, 1.80 mmol) and Pd/C (10% w/w, 1.20 g) in MeOH (100 mL). The resulting suspension is deoxygenated and then flushed with H2 gas for 15 min. Finally, the reaction mixture is vigorously stirred at rt under a static H2 atmosphere maintained with a balloon. After 2 h, quantitative consumption of compound B1 can be discerned. The reaction vessel is then vigorously purged with N2 and the suspension is filtered through a bed of Celite and SiO2. After washing the insolubles with copious quantities of CH2Cl2 and EtOAc, the filtrate is concentrated in vacuo to the title compound as a mixture of four diastereomers (1.116 g, 95% crude yield, ES−=648.9). This material is used further without purification.

Provenance & Evidence