HCID 5052632, compound → HCID 22638468, compound

HRID 1715529Notes

Reaction equation

HRID 1715529 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[N:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[N+:25]([O-])=O)[N:9]=2)=[CH:4][CH:3]=1>O1CCOCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17]([C:18]3[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=3)=[N:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[NH2:25])[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 5052632HCID 5052632, compound

Product 1

HCID 22638468HCID 22638468, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.02 g of 2,3-di(4-methylphenyl)-5-nitroquinoxaline was dissolved in 30 g of dioxane, followed by purging with argon and adding 0.6 g of 5% Pd/C (hydrous). After purging with argon again, the system was purged with hydrogen for reaction at room temperature for 18 hours. After completion of the reaction, the system was filtered. The filtration residue was washed with acetone and then with dioxane and filtered again. The solvent was removed from the resulting filtrate, followed by extracting a reaction product by use of a silica gel column.

Workup

  1. customby purging with argon
  2. additionadding 0.6 g of 5% Pd/C (hydrous)
  3. customAfter purging with argon again
  4. customthe system was purged with hydrogen for reaction at room temperature for 18 hours
  5. customAfter completion of the reaction
  6. filtrationthe system was filtered
  7. washThe filtration residue was washed with acetone
  8. filtrationwith dioxane and filtered again
  9. customThe solvent was removed from the resulting filtrate
  10. extractionby extracting a reaction product by use of a silica gel column

Sources & evidence

ORD record
ord-08b2bdc026394b31aed5207bba5cd5fd
Source dataset
uspto-grants-2010_09
Patent number
US07799894B2

Reaction notes

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