Sodium Carbonate → HCID 59467506, compound

Participants

Reaction Steps

4.5 g N-(2-chloro-pyridin-3-yl)-N-methyl-2-trifluoromethyl-benzamide (14.3 mmol), 2.2 g tetrakis(triphenylphosphine) palladium (Pd(PPh3)4) (1.4 mmol), 9.7 g sodium carbonate (Na2CO3) (71.5 mmol), and 50 mL N,N-dimethyl acetamide (DMA) were added in a flask and reacted for 18 hr under nitrogen. After cooling to room temperature, the reaction was quenched by water. After filtration, concentration, and purification by column, 3.73 light yellow solid was obtained, with a yield of 94%.

Provenance & Evidence