HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → 4-{[4-(4-Bromophenyl)pyrimidin-2-yl]amino}benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 1-(4-Bromophenyl)-3-(dimethylamino)-2-propen-1-one | HCID 617244 | — |
| Reactant | HCID 178512579 | HCID 178512579 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-{[4-(4-Bromophenyl)pyrimidin-2-yl]amino}benzenesulfonamide | HCID 57446797 | 99.9% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A flask is charged with the 1-(4-bromo-phenyl)-3-dimethylamino-propenone (1.05 g, 4.10 mmol), 4-guanidino-benzenesulfonamide (1.33 g, 6.20 mmol), and NMP (30 ml). The reaction mixture is stirred at 120° C. for 20 h. The reaction mixture is cooled to room temperature, diluted with water, and filtered. The solid residue is washed with water and dried to yield 1.66 g of a white solid. MS (ESI) m/z 405.1; HRMS: calcd for C16H13BrN4O2S+H+, 405.00153; found (ESI-FTMS, [M+H]1+), 405.00158.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799915B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-d4748d8351f64745925345778e099815 |
| Source note | uspto-grants-2010_09 |