(2S)-1,1,2-Triphenyl-1,2-ethanediol → Esomeprazole

Participants

Reaction Steps

A suspension of omeprazole (20 g, 57.9 mmol) and (S)-1,1,2-triphenyl-1,2-ethanediol (25.2 g, 86.9 mmol) in ethanol (700 ml) at ambient temperature was stirred for 30 h. The solid was filtered, was washed with ethanol (2×150 ml) and was dried in vacuo to afford (S)-omeprazole.2[(S)-1,1,2-triphenyl-1,2-ethanediol] (24.1 g, 90%, 95.5% e.e.) as a white powder.

Provenance & Evidence