HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Irbesartan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Irbesartan hydrochloride | HCID 11568906 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Irbesartan | HCID 3749 | — |
Reaction Steps
100 g of anhydrous irbesartan hydrochloride was taken in a mixture of 250 ml toluene and 250 ml water. The pH of the reaction mass was adjusted to 6.5 to 7.0 with aqueous ammonia at 25-30° C. and stirred for about 30 minutes and filtered. The product was dried at 60° C. under vacuum to yield Form A of irbesartan free base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799928B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-63630d540c32495c932d321ae0909986 |
| Source note | uspto-grants-2010_09 |