4-Cyanobenzoyl chloride → 4-[3-(1-Cyclopropylpiperidin-4-yl)[1,2,4]oxadiazol-5-yl]benzonitrile

HRID 1715766Notes

Reaction equation

HRID 1715766 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]([NH:12][OH:13])=[NH:11])[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[C:14]([C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=O)=[CH:18][CH:17]=1)#[N:15]>>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[N:11]=[C:20]([C:19]4[CH:23]=[CH:24][C:16]([C:14]#[N:15])=[CH:17][CH:18]=4)[O:13][N:12]=3)[CH2:6][CH2:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 801724-Cyanobenzoyl chlorideHCID 178513372HCID 178513372, compound

Product 1

HCID 596577884-[3-(1-Cyclopropylpiperidin-4-yl)[1,2,4]oxadiazol-5-yl]benzonitrile

Procedure

The title compound was prepared by a similar procedure to that described in Example 35a, starting from 1-cyclopropyl-N-hydroxypiperidine-4-carboxamidine and 4-cyanobenzoyl chloride.

Sources & evidence

ORD record
ord-499c37d3635d44f88371250e5071553d
Source dataset
uspto-grants-2010_09
Patent number
US07799924B2

Reaction notes

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