Water → HCID 68435626, compound

Participants

Reaction Conditions

Reaction Steps

1-(3,5-Dimethyl-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (0.40 g, 1.17 mmol) was suspended in ethanol (2.00 mL) and treated with 3N KOH in water (1.17 mL, 3.51 mmol). The mixture was warmed at 50° C. and stirred for 1 hour, then warmed at 70° C. and stirred for 20 min. After cooling to room temperature, the volatiles were evaporated. The residue was dissolved in water (1.00 mL) and the pH set to 1 with 2N HCl. The precipitate was filtered, washing with water, then dried under high vacuum. 1-(3,5-Dimethyl-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid was obtained as an off-white solid, 0.38 g (98%), MS (ISP): m/e=330.3 (M−H).

Provenance & Evidence