4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 86621009, compound

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Reaction Steps

The title compound was prepared as for example 8, steps 1 to 4. Step 1 was performed using 3-chlorobenzensulfonyl chloride and yielded 1-(3-chloro-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester) which was hydrolyzed to 1-(3-chloro-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid in step 2 and coupled to (2-amino-thiazol-4-yl)-acetic acid ethyl ester in step 3 to yield (2-{[1-(3-chloro-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-thiazol-4-yl)-acetic acid ethyl ester. This was hydrolyzed to (2-{[1-(3-chloro-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-thiazol-4-yl)-acetic acid in step 4: white solid, 0.08 g (96%), MS (ISP): m/e=476.0 (M−H).

Provenance & Evidence