(5-Amino-[1,2,4]thiadiazol-3-yl)-acetic acid allyl ester → (5-{[1-(2-Methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-[1,2,4]thiadiazol-3-yl)-acetic acid allyl ester

Participants

Reaction Steps

1-(2-Methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carboxylic acid was converted to the title compound in analogy to example 8, steps 3 and 4. Step 3 was performed using (5-amino-[1,2,4]thiadiazol-3-yl)-acetic acid allyl ester and 1-(2-methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carboxylic acid and yielded (5-{[1-(2-methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-[1,2,4]thiadiazol-3-yl)-acetic acid allyl ester, which was hydrolyzed to (5-{[1-(2-methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-[1,2,4]thiadiazol-3-yl)-acetic acid in step 4, MS (ISP): m/e=501.1 (M−H).

Provenance & Evidence