Sodium Acetate → HCID 22065264, compound

Participants

Reaction Conditions

Reaction Steps

0.157 g of 1-(2,4-dihydroxyphenyl)-2-(3′,4′-dihydroxyphenyl)-1-oxo-3-bromo-propane, the major product of step 3 in Example 3, and about 2 molar equivalents of sodium acetate ware mixed with 88 mL of methanol and heated at about 60° C. for 4 hours. After cooling, the mixture was acidified to pH 5 and the methanol was removed under reduced pressure. The residue was dissolved in ethyl acetate (50 mL) and the solution was washed with water and concentrated. The crude product was separated by column chromatography to yield approximately equal amounts of 1-(2,4-dihydroxyphenyl)-2-(3′,4′-dihydroxy-phenyl)-1-oxo-2-propene and 7-hydroxy-(3′,4′-dihydroxyphenyl)-2,3-dihydroisoflavone.

Provenance & Evidence