Trifluoroacetic acid → HCID 11406249, compound

Participants

Reaction Steps

The general hydrolysis procedure described for 195 was followed. (1,1-dimethylethyl (2E/2Z)-3-{4-[cyclooctylidene(4-hydroxyphenyl)methyl]phenyl}-2-methyl-2-propenoate (214) (0.200 g, 0.46 mmol) was treated with TFA to afford 0.160 g (92%) of the title compound 215 as a mixture of E and Z (˜65:35) isomers. The pure E isomer was isolated by HPLC to afford the title compound 214 as a white solid.

Provenance & Evidence