Methanol → HCID 23074222, compound

HRID 1716198Notes

Reaction equation

HRID 1716198 reaction equation
[NH2:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[C:3]([OH:5])=[O:4].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[NH2:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH3:15])=[O:4]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 227939(+-)-2-Aminoheptanoic acid

Product 1

HCID 23074222HCID 23074222, compound

Conditions

Temperature
60 °C

Procedure

To a suspension of 2.18 g of 2-aminoheptanoic acid in 50 ml of methanol was dropwise added 2.19 g of thionyl chloride (manufactured by WAKO PURE CHEMICAL INDUSTRIES LTD.), and the mixture was stirred overnight at 60° C. Methanol and thionyl chloride were removed by evaporation and the residue was washed with 20 ml of ether to obtain 2.84 g of the title compound.

Workup

  1. customMethanol and thionyl chloride were removed by evaporation
  2. washthe residue was washed with 20 ml of ether

Sources & evidence

ORD record
ord-b71af3238fdf4d8a9ccdaeed5fd2d9e1
Source dataset
uspto-grants-2010_09
Patent number
US07803792B2

Reaction notes

Loading…