2-(2-Benzothiazolylthio)acetic acid → 2-(Benzothiazol-2-ylsulfanyl)-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

HRID 1716249Notes

Reaction equation

HRID 1716249 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]([OH:14])=O.[CH3:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[NH:24][CH2:23][CH2:22][CH2:21]2>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]([N:24]1[C:25]2[C:20](=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:15])[CH2:21][CH2:22][CH2:23]1)=[O:14]

Participants

3

Reactant 2

HCID 805252-(2-Benzothiazolylthio)acetic acidHCID 27741668-Methyl-1,2,3,4-tetrahydroquinoline

Product 1

HCID 594678942-(Benzothiazol-2-ylsulfanyl)-1-(8-methyl-3,4-dihydro-2H-quinolin-1-yl)-ethanoneYield 39%

Procedure

The title compound was synthesized according to General Procedure B using 2-(benzo[d]thiazol-2-ylthio)acetic acid and 8-methyl-1,2,3,4-tetrahydroquinoline to yield 46 as a white solid (39%): MS m/z: 355 (M+H)+. Anal. Calcd. For, C19H18N2OS2: C, 64.38; H, 5.12; N, 7.90; S, 18.09. Found: C, 64.37; H, 5.02; N, 7.74; S, 18.10.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-7009e53d830140319596ee211d4f92ba
Source dataset
uspto-grants-2010_09
Patent number
US07803790B2

Reaction notes

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