(4-chloro-2-Methylphenoxy)acetic acid → HCID 909478, compound

HRID 1716256Notes

Reaction equation

HRID 1716256 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=O)=[C:4]([CH3:13])[CH:3]=1.[NH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([N:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17][CH2:16][CH2:15]2)=[O:10])=[C:4]([CH3:13])[CH:3]=1

Participants

3

Reactant 2

HCID 7204(4-chloro-2-Methylphenoxy)acetic acidHCID 694601,2,3,4-Tetrahydroquinoline

Product 1

HCID 909478HCID 909478, compoundYield 46%

Procedure

The title compound was synthesized according to General Procedure D using 2-(4-chloro-2-methylphenoxy)acetic acid and compound 3 to yield compound 56 (365 mg, 46%): MS (APCI): m/z 316 [M+H]+. Anal. Calcd. for C18H18ClNO2: C, 68.46; H, 5.75; N, 4.44. Found: C, 68.41; H, 5.92; N, 4.51.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-face0ac2c8ba4faaa478980f6092d4ab
Source dataset
uspto-grants-2010_09
Patent number
US07803790B2

Reaction notes

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