HCID 68675669, compound → Ammonia

Participants

Reaction Conditions

Reaction Steps

5-[4-(5-Amino-pentyl)-piperazin-1-yl]pentylamine trifluoroacetate (Intermediate P) (172 mg, 0.24 mmol) is added to a stirring solution of 1-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-2-methyl-isothiourea hydroiodide (93 mg, 0.48 mmol) in DMF (1 mL). The resulting mixture is heated to 50° C. for 8 hours and then allowed to cool to RT. The reaction mixture is quenched with 5% citric acid solution and addition of DCM results in the formation of a gum. The gum is isolated and dissolved in MeOH (2 mL). The solution is passed through a “capture release” SCX-2 cartridge eluting with 1 N ammonia in MeOH followed by 1:1 MeOH:ammonia solution to afford the title compound.

Provenance & Evidence