Trifluoroacetic acid → N~1~,N~4~-Bis(4-aminobutyl)benzene-1,4-dicarboxamide

Participants

Reaction Steps

{4-[4-(4-tert-Butoxycarbonylamino-butylcarbamoyl)-benzoylamino]-butyl}-carbamic acid tert-butyl ester (0.49 g) is treated with neat TFA (5 mL) and allowed to stand at RT overnight. The acid is removed in vacuo to afford the title compound as a yellow solid. Alternatively, deprotection can be carried out using 33% HBr is acetic acid. [M+H]+ 307.22

Provenance & Evidence