Methanesulfonic Acid → 4-(4-Chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-(R)-yl)-benzenesulfonamide

Participants

Reaction Steps

To a solution of 257 mg of N-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-(R)-yl)-4-(4-chloro-phenoxy)-benzenesulfonamide from Step E was added 6 mL of methane sulfonic acid. The reaction was stirred at room temperature for 16 hours. The reaction was poured over ice, and 50 mL of H2O was added. The resulting solids were filtered, washed with H2O (4 times), and dried. The solids were dissolved in ethyl acetate, and Hexanes was added after solvent reduction under vacuum. The resulting solids were filtered and washed with Hexanes (3 times), followed by drying. Obtained was 195 mg of a white solid (Compound 1). MS: 839 (2M+Na), 431 (M+Na), 409 (M+H).

Provenance & Evidence