反应详情

To a solution of 3-amino-2-bromo-pyridine (0.4 g, 2.3 mmol) in dichloromethane (4 ml) and pyridine (4 ml) was added 4-fluoro-benzenesulfonylchloride (0.45 g, 2.3 mmol) in one portion. The mixture was stirred overnight. The mixture was diluted with dichloromethane and washed with saturated NaCl solution. The organic layer was dried over sodium sulfate and concentrated. The crude product was purified through chromatography (2-5% EtOAc in dichloromethane). MS 331.8 (M+H)+

1. washwashed with saturated NaCl solution
2. dry with materialThe organic layer was dried over sodium sulfate
3. concentrationconcentrated
4. customThe crude product was purified through chromatography (2-5% EtOAc in dichloromethane)