4'-Chlorobiphenyl-4-sulfonyl chloride → 4'-Chloro-biphenyl-4-sulfonic acid (1-benzyloxy-2-oxo-1,2-dihydro-pyridin-3-yl)-amide

HRID 1716286Notes

Reaction equation

HRID 1716286 reaction equation
Br.[NH2:2][C:3]1[C:4](=[O:17])[N:5]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1>>[CH2:10]([O:9][N:5]1[CH:6]=[CH:7][CH:8]=[C:3]([NH:2][S:31]([C:28]2[CH:27]=[CH:26][C:25]([C:22]3[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=3)=[CH:30][CH:29]=2)(=[O:32])=[O:33])[C:4]1=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 27947454'-Chlorobiphenyl-4-sulfonyl chlorideHCID 685144493-amino-1-benzyloxy-1H-pyridin-2-one hydrogen bromide salt

Product 1

HCID 866199374'-Chloro-biphenyl-4-sulfonic acid (1-benzyloxy-2-oxo-1,2-dihydro-pyridin-3-yl)-amide

Procedure

The titled compound was prepared from 3-amino-1-benzyloxy-1H-pyridin-2-one hydrogen bromide salt from Step E and 4′-chloro-biphenyl-4-sulfonyl chloride according to the procedure described in Example 32 Step A. MS 467 (M+H)+.

Sources & evidence

ORD record
ord-29ce8e33dbe2457aa29aba3f7f8f2bb4
Source dataset
uspto-grants-2010_09
Patent number
US07803793B2

Reaction notes

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