HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716308Generated: October 26, 2026
P-Cresol → 1-Chloromethanesulfonyl-4-(p-tolyloxy)-benzene
https://huagongshe.com/reaction/1716308
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Cresol | HCID 2879 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Chloromethanesulfonyl-4-fluoro-benzene | HCID 58904791 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-Chloromethanesulfonyl-4-(p-tolyloxy)-benzene | HCID 68513944 | — |
Reaction Steps
A mixture of 1-chloromethanesulfonyl-4-fluoro-benzene (0.5 g, 2.4 mmol) from Step A, 4-methyl-phenol (0.21 mL, 2.0 mmol) and K2CO3 (0.55 g, 4.0 mmol) in dry DMA (10 mL) was heated at 95° C. overnight. The reaction mixture was diluted with EtOAc and water. After the usual work-up, crude product was purified by chromatography (silica gel, 25% EtOAc/hexanes). MS 319 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07803793B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-24c16028d9694a67a62658e6fc25272c |
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| Source note | uspto-grants-2010_09 |
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