1-Hydroxybenzotriazole → 2-(4-Fluoro-phenylsulfanyl)-N-trityloxy-acetamide

Participants

Reaction Steps

A mixture of (4-fluoro-phenylsulfanyl)-acetic acid (1.52 g, 8.17 mmol) from step B and O-Trityl-hydroxylamine (2.26 g, 10 mmol) in dry DMF was sequentially added NMP (3.0 ml), EDCl (2.05 g, 10.7 mmol), and HOBT (1.45 g, 10.74 mmol). The resulting mixture was stirred at room temperature for overnight. The reaction was diluted with EtOAc and water. The organic layer was washed sequentially with 1N HCl solution, 10% aqueous Na2CO3, water and saturated NaCl solution. The organic portion was dried over anhydrous Na2SO4 and concentrated under reduced pressure to gave a crude material, which was then purified by a column chromatography with 0˜25% EtOAc in hexanes. MS: 466.0 (M+H)+.

Provenance & Evidence