HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 11389645, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Cyclohexene-1-carboxylic acid | HCID 20903 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 19914-92-2 | HCID 11402498 | — |
| Reactant | HCID 86761182 | HCID 86761182 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11389645 | HCID 11389645 | — |
Reaction Steps
The title compound was prepared, in racemic form, by generating (1R*,3R*,4R*)-4-iodocyclohexane-1,3-carbolactone from cyclohex-3-ene carboxylic acid, which was then treated with the base DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) to eliminate HI. The resultant (1R*,5S*)-cyclohex-3-ene-1,5-carbolactone was then treated with potassium hydroxide dissolved in ethanol to yield the title compound (Marshall, J. A., and Shiping, X., 1995)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803808B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-b99d0e9fce07440183d935fda2c906d9 |
| Source note | uspto-grants-2010_09 |