Sodium Hydroxide → HCID 11359228, compound

HRID 1716360Notes

Reaction equation

HRID 1716360 reaction equation
[OH-].[Na+].[NH2:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([C:19]([O:21]CC)=[O:20])[C:11]=2[CH3:24])=[O:9])=[CH:6][C:5]=1[O:27][CH3:28]>O1CCOCC1>[NH2:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([C:19]([OH:21])=[O:20])[C:11]=2[CH3:24])=[O:9])=[CH:6][C:5]=1[O:27][CH3:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12069605HCID 12069605, compound

Product 1

HCID 11359228HCID 11359228, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

30 ml of 2 N sodium hydroxide are added to 2.1 g (5.96 mmol) of ethyl 3-(4-amino-3-methoxybenzoyl)-2-methyl-1-indolizinecarboxylate in solution in 30 ml of dioxane, and the medium is heated under reflux for 20 hours. The reaction medium is concentrated under reduced pressure.

Workup

  1. temperaturethe medium is heated
  2. temperatureunder reflux for 20 hours
  3. concentrationThe reaction medium is concentrated under reduced pressure

Sources & evidence

ORD record
ord-501aa2d6f0444c1489ef71c17a584f48
Source dataset
uspto-grants-2010_09
Patent number
US07803811B2

Reaction notes

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