Sodium Hydroxide → HCID 68706657, compound

HRID 1716362Notes

Reaction equation

HRID 1716362 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:17]=[C:16]([C:18]([C:20]2[N:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[C:22]([O:29][CH3:30])[C:21]=2[CH3:31])=[O:19])[CH:15]=[CH:14][C:6]=1[NH:7][CH2:8][C:9]([O:11]CC)=[O:10]>C(O)C>[CH3:3][O:4][C:5]1[CH:17]=[C:16]([C:18]([C:20]2[N:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[C:22]([O:29][CH3:30])[C:21]=2[CH3:31])=[O:19])[CH:15]=[CH:14][C:6]=1[NH:7][CH2:8][C:9]([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68707120HCID 68707120, compound2×

Product 1

HCID 68706657HCID 68706657, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.15 ml of 1 N sodium hydroxide are added to 1 g (2.52 mmol) of ethyl 2-{2-methoxy-4-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]anilino}acetate, a compound obtained in Example 195, in solution in 10 ml of ethanol, and the medium is stirred at room temperature overnight. The reaction medium is concentrated under reduced pressure. The residue is taken up in water, washed with ethyl ether and separated after settling out. The aqueous phase is neutralized with 1 N hydrochloric acid. The precipitate formed is filtered off, washed with water, dried and then taken up in ethyl ether, filtered and dried. A yellow powder is obtained.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. washwashed with ethyl ether
  3. customseparated
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water
  7. customdried
  8. filtrationfiltered
  9. customdried
  10. customA yellow powder is obtained

Sources & evidence

ORD record
ord-e89566bbef8a4f21836c61c50ae2b743
Source dataset
uspto-grants-2010_09
Patent number
US07803811B2

Reaction notes

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