Ethyl chloroformate → HCID 68708986, compound

HRID 1716365Notes

Reaction equation

HRID 1716365 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])=[CH:4][C:3]=1[O:22][CH3:23].Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH3:23][O:22][C:3]1[CH:4]=[C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])[CH:6]=[CH:7][C:2]=1[NH:1][C:25](=[O:26])[O:27][CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 11335885HCID 11335885, compound

Product 1

HCID 68708986HCID 68708986, compound

Procedure

This compound was obtained according to the same procedure as that described in Example 199 by acylation of (4-amino-3-methoxyphenyl)(1-methoxy-2-methylindolizin-3-yl)methanone with ethyl chloroformate. The product is purified by flash chromatography on silica, eluting with dichloromethane. A yellow powder is obtained.

Workup

  1. customThis compound was obtained
  2. customThe product is purified by flash chromatography on silica
  3. washeluting with dichloromethane
  4. customA yellow powder is obtained

Sources & evidence

ORD record
ord-6b255062f8184136949ba4e1e5a7df33
Source dataset
uspto-grants-2010_09
Patent number
US07803811B2

Reaction notes

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