1,2-Dichloroethane → HCID 12294579, compound

Participants

Reaction Steps

To a stirred solution of 0.300 g (1.86 mmol) of 1H-indole-2-carboxylic acid in CH2Cl2 (10 ml) was added 0.428 g (2.23 mmol) of EDC, 0.302 g (2.23 mmol) of HOBt, 0.28 ml (2.04 mmol) of Et3N and 0.17 ml (2.04 mmol) of pyrrolidine. The reaction mixture was stirred at RT over the night and then poured onto water and extracted with CH2Cl2. The combined organic phases were dried over Na2SO4 and concentrated in vacuo. Re-crystallization in Et2O afforded 0.31 g (78%) of (1H-indol-2-yl)-pyrrolidin-1-yl-methanone as white crystals.

Provenance & Evidence