HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716422Generated: November 1, 2026
Lithium hydroxide, monohydrate → 6-Chloro-1-[2-(dimethylamino)ethyl]-1H-indole-3-carboxylic acid
https://huagongshe.com/reaction/1716422
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 68504879 | HCID 68504879 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 6-Chloro-1-[2-(dimethylamino)ethyl]-1H-indole-3-carboxylic acid | HCID 68511211 | — |
Reaction Steps
The ester was hydrolyzed in a mixture of H2O/THF/MeOH (ratio 1:1:1) with LiOH.H2O (3 eq.). The reaction mixture was stirred at 40° C. overnight. The acid was extracted several times with EtOAc, and the combined organic phases were dried over Na2SO4. Recrystallisation in Et2O afforded 35 mg (34% overall yield) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07803815B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-759ab8b291944e1bb2b19d53d93adfb6 |
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| Source note | uspto-grants-2010_09 |
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