反应详情

To a solution of 1-(6-chloro-1H-indol-3-yl)-2,2,2-trifluoro-ethanone (described in US 2004067939) in CH2Cl2 (in the presence of 0.4 nM molecular sieve) were added anhydrous Cu(OAc)2 (2 eq.), 3,5-difluorophenylboronic acid (3 eq.) and pyridine (4 eq.). The reaction mixture was stirred at RT for 16 h under an air atmosphere, filtered over decalite, washed with CH2Cl2 and concentrated in vacuo. Chromatography (hexane/EtOAc: 9:1) gave the title compound in 71% yield.

1. filtrationfiltered over decalite
2. washwashed with CH2Cl2
3. concentrationconcentrated in vacuo