HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716426Generated: November 2, 2026
Sodium Hydroxide → 6-Chloro-1-(3,5-difluorophenyl)-1H-indole-3-carboxylic acid
https://huagongshe.com/reaction/1716426
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-[6-Chloro-1-(3,5-difluoro-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-ethanone | HCID 86610163 | — |
| Product | 6-Chloro-1-(3,5-difluorophenyl)-1H-indole-3-carboxylic acid | HCID 68507603 | 70% |
Reaction Steps
A suspension of 1-[6-chloro-1-(3,5-difluoro-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-ethanone in 3N aqueous NaOH was stirred at 70° C. for 48 h. After washing with CH2Cl2, the aqueous phase was acidified to pH 1 and extracted with CH2Cl2. Concentration in vacuo gave the title compound in 70% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07803815B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-620f921d914144b19484cc26b48144fb |
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| Source note | uspto-grants-2010_09 |
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