Sodium hydride → HCID 16059602, compound

Participants

Reaction Steps

To a stirred solution of 30 mg of 1-[1-(6-chloro-1H-indole-3-carbonyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one in 1 ml of DMF were added 1.1 eq. of NaH (55% in oil). The reaction mixture was stirred for 30 min. before the addition of 1.2 eq. of 2-chloro-1-piperidin-1-yl-ethanone. The crude reaction mixture was directly purified by preparative HPLC to afforded 4 mg of the title compound as a white powder.

Provenance & Evidence