Triethylamine → HCID 25054438, compound

Participants

Reaction Steps

At ambient temperature a solution of 0.16 g (0.93 mmol) of 5-fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride in 2 ml of dichloromethane was added dropwise to a solution of 0.15 g (0.85 mmol) of N-cyclopropyl-1-pyridin-4-yl-propylamine and 0.14 ml of triethylamine in 5 ml of dichloromethane. The reaction mixture was stirred for 12 hrs at ambient temperature and then at 40° C. for 8 hrs and washed with water. The organic layers were filtrated over basic alumina and dried. Column chromatography (gradient dichloromethane/Methanol) yielded 0.18 mg (44% yield) of N-cyclopropyl-N-[1-pyridin-4-yl-propyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (M+H=317).

Provenance & Evidence