4-Iodo-2-(trifluoromethyl)pyridine → (S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

HRID 1716470Notes

Reaction equation

HRID 1716470 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C@H:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:5]I.I[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=1>>[CH3:1][O:2][C:3](=[O:14])[C@@H:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:5][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=1

Participants

3

Reactant 2

HCID 234369404-Iodo-2-(trifluoromethyl)pyridineHCID 86614124(R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate

Product 1

HCID 67165305(S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

Procedure

The title compound was prepared according to previously reported procedure (U.S. patent application Ser. No. 11/575,187) from (R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-iodo-2-(trifluoromethyl)pyridine (this starting material was prepared according to a procedure described in Eur. J. Org. Chem. 2003, 1559-1568).

Sources & evidence

ORD record
ord-0237d4cba3d54f60b7a1a291b9737841
Source dataset
uspto-grants-2010_09
Patent number
US07803809B2

Reaction notes

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