反应详情

2-Bromo-6-hydroxymethylpyridine (5.00 g, 25.5 mmol) was dissolved in chloroform (30 ml) and thionyl chloride (2.8 ml, 38.3 mmol) was added, and the mixture was stirred at room temperature for 3 hours. After the reaction solution was concentrated, a saturated aqueous sodium bicarbonate was added to the residue and the precipitates were collected by filtration. After washing with water, the precipitates were dried in vacuo to give the title compound (5.20 g, 99%).

1. concentrationAfter the reaction solution was concentrated
2. additiona saturated aqueous sodium bicarbonate was added to the residue
3. filtrationthe precipitates were collected by filtration
4. washAfter washing with water
5. customthe precipitates were dried in vacuo