2-Amino-4-methylpyridine → HCID 44178123, compound

Participants

Reaction Conditions

Reaction Steps

4-[5-(6-bromopyridin-2-yl)thiazol-2-yl]-1-methylpiperazin-2-one obtained in Step 5 (188 mg, 0.53 mmol) was dissolved in toluene (5 ml), and after 2-amino-4-methylpyridine (58 mg, 0.53 mmol) was added, 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (66 mg, 0.11 mmol), palladium acetate (18 mg, 0.08 mmol) and cesium carbonate (260 mg, 0.80 mmol) were added and the mixture was stirred overnight at 100° C. Water was added to the reaction solution and extracted with ethyl acetate and the organic layer was washed with a saturated saline solution. The organic layer was dried over sodium sulfate and after vacuum concentration, the residue was washed with methanol and the title compound (77 mg, 38%) was obtained.

Provenance & Evidence