Ammonium Chloride → HCID 44178124, compound

Participants

Reaction Steps

1-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl} piperidine-4-carboxylic acid (100 mg, 0.25 mmol) obtained in Example 2 was dissolved in N,N-dimethylformamide (2 ml) and benzotriazolyloxy trispyrrolidino phosphonium hexafluorophosphate (263 mg, 0.50 mmol), diisopropylethylamine (0.18 ml, 1.03 mmol) and ammonium chloride (41 mg, 0.77 mmol) were added and the mixture was stirred at room temperature for 1 hour. A saturated aqueous sodium bicarbonate was added to the reaction solution and the precipitated solid was collected by filtration and washed with water and title compound (89 mg, 89%) was obtained.

Provenance & Evidence