Acetic Anhydride → HCID 58706903, compound

Participants

Reaction Steps

Acetic anhydride (0.02 ml, 0.24 mmol) was added to a solution of N—((S)-1-{5-[6-(4-methyllpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}ethyl)amine (50 mg, 0.16 mmol) obtained in Example 9 in pyridine (3 ml) and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated and extracted with a mixed solution of ethyl acetate-tetrahydrofuran. The organic layer was washed with a saturated brine and dried over magnesium sulfate. The obtained residue was washed with diisoprpyl ether and dried in vacuo and the title compound (43 mg, 76%) was obtained.

Provenance & Evidence