Hydrogen chloride-ethyl acetate → HCID 86607642, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-4-[5-(6-bromopyridin-2-yl)thiazol-2-yl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (5.00 g, 11.4 mmol) obtained in Step 2 in tetrahydrofuran (30 ml) was added 4N hydrogen chloride-ethyl acetate solution (30 ml) and heated to reflux at 90° C. for 2 hours. After the reaction solution was cooled, it was concentrated and washed with ethyl ether and dried, and the title compound (3.57 g) was obtained.

Provenance & Evidence