HCID 58706768, compound → HCID 58706673, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2,2-dimethyl-4-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}oxazolidine-3-carboxylic acid tert-butyl ester (1.90 g, 4.06 mmol) obtained in Example 12 in tetrahydrofuran (10 ml), 4N hydrogen chloride-ethyl acetate solution (10 ml) was added and stirred at 60° C. for 5 hours. After the reaction solution was concentrated, it was neutralized with a saturated aqeous sodium bicarbonate, and extracted with ethyl acetate. After the organic layer was washed with a saturated brine and dried over magnesium sulfate, it was concentrated and the residue was purified by flash chromatography on silica gel (chloroform:methanol=20:1) and the title compound (588 mg, 44%) was obtained.

Provenance & Evidence