Trifluoroacetic acid → HCID 68421545, compound

Participants

Reaction Steps

Trifluoroacetic acid (20 ml) was added to a solution of (1-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)acetic acid tert-butyl ester (4.30 g, 9.23 mmol) obtained in Step 3 in chloroform (20 ml) and the solution was stirred overnight at room temperature. Subsequently 4N hydrochloric acid-ethyl acetate solution (20 ml) was added to the concentrate obtained by concentrating the reaction solution in vacuo, and the precipitated solid was collected by filtration, washed with ethyl acetate (20 ml) and the title compound (4.46 g, 100%) was obtained.

Provenance & Evidence